EMD-281014 hydrochloride

Research use only, not for human use.

EMD-281014 hydrochloride ((Pruvanserin, LSN2411347, LY-2422347)) is a potent, highly selective 5-HT2A antagonist with Ki of 0.87 nM.

EMD-281014 hydrochloride ((Pruvanserin, LSN2411347, LY-2422347)) is a potent, highly selective 5-HT2A antagonist with Ki of 0.87 nM, displays little to no affinity for 5-HT2C receptors (Ki=557 nM), human D2 receptors and IKr channels; significantly increases swimming and decreases immobility in male congenital learned helpless rats in the forced swim test; reduces dyskinesia and psychosis in the l-DOPA-treated parkinsonian marmoset.Sleep Disorder Discontinued

Pruvanserin;LSN2411347;LY-2422347

Endocrinology/Hormones

5-HT Receptor

5-HT Receptor

Neurological Disease

Sleep Disorder

443144-27-2

412.89

C22H22ClFN4O

>98% (HPLC)

——

C1CN(CCN1CCC2=CC=C(C=C2)F)C(=O)C3=CC=CC4=C3NC=C4C#N.Cl

7-[[4-[2-(4-Fluorophenyl)ethyl]-1-piperazinyl]carbonyl]-1H-indole-3-carbonitrile hydrochloride

(-20℃)

With Ice Pack

≥ 2 years